Cosmetic Active System
Madecassoside
A Centella asiatica triterpenoid active for soothing, barrier-support, antioxidant, and sensitive-skin skincare formulas.
Centella-derived active ingredient for sensitive-skin, Cica repair, barrier-support, redness appearance care, and recovery-focused cosmetic formulations.
MA90 / MA85 / MA20 / MA10
Formulation support
Technical grade recommendation
INCI
Madecassoside
CAS
34540-22-2
Function
Soothing, barrier support, redness appearance care, antioxidant support, sensitive-skin comfort, recovery-focused cosmetic care
Recommended Dosage
0.05–0.2%
Shelf Life
24 Months
Product Overview
What is Madecassoside?
Madecassoside is one of the key active compounds associated with Centella asiatica. In cosmetic formulation, it is used as a Centella-derived active for soothing, sensitive-skin, redness appearance care, barrier-support, and recovery-focused skincare concepts.
Defined active identity
Unlike a broad botanical extract, Madecassoside refers to a more defined active molecule. This gives formulators, procurement teams, and brand owners a clearer ingredient positioning, stronger Cica active story, and more precise grade selection.
B2B product logic
Madecassoside can be used as a hero active in premium serums, ampoules, and repair creams. It can also be used as a supporting active in toners, lotions, gels, sheet masks, and cost-balanced OEM/ODM product lines.
01
Match Your Required Spec
Tell us your target application, use level, assay requirement, solubility needs, and document requirements. We help confirm whether our Madecassoside specification matches your formulation or sourcing project.
02
Test It in Your Formula
We support sample evaluation for serums, creams, toners, masks, cleansers, body care, and strong-active systems. Use level, compatibility, processing conditions, and stability should be verified in your final formula.
03
Prepare for Commercial Order
For bulk purchasing, we help confirm COA, TDS, MSDS, specification, MOQ, lead time, packaging, shipping documents, and batch consistency before commercial approval.
Buyer decision path
Why B2B buyers choose Madecassoside
01
Sensitive skin positioning
Supports formulas designed for visible comfort, calmer-looking skin, and sensitive-skin product concepts.
02
Cica repair concept
Provides a more defined Centella-derived active than generic Centella extract.
03
Barrier-support skincare
Works well with panthenol, ceramides, ectoin, beta-glucan, and humectants.
04
Redness appearance care
Helps build products for redness-prone-looking and stressed-looking skin.
05
OEM/ODM flexibility
Multiple grades support premium, commercial, and cost-balanced product lines.
06
Technical differentiation
Gives R&D, procurement, and marketing teams a clearer ingredient explanation.
Grade selection guide
Choose the right Madecassoside grade for your formula and price tier
Noyain supplies Madecassoside in MA90, MA85, MA20, and MA10 grade directions. Each grade serves a different formulation and commercial purpose.
MA90
Premium high-purity grade
Choose MA90 when Madecassoside is central to the product story. It is suitable for premium sensitive-skin serums, high-end Cica ampoules, post-procedure cosmetic care products, and dermatology-inspired skincare.
MA85
High-purity balanced grade
Choose MA85 when the project requires high-purity Madecassoside direction but also needs stronger commercial flexibility than MA90.
MA20
Practical standardized grade
Choose MA20 when Madecassoside is part of a broader soothing or barrier-support system for toners, lotions, masks, gels, and larger-volume OEM/ODM skincare projects.
MA10
Cost-efficient supporting grade
Choose MA10 when Madecassoside is used mainly for cost-efficient Centella-derived active positioning in large-volume or entry-level products.
Formulation benefits
Key benefits for cosmetic formulation
Madecassoside helps formulators build more credible Cica, sensitive-skin, and barrier-support skincare products. Compared with a general Centella extract, it provides a more defined active ingredient story and clearer grade selection for B2B product development.
01
Clearer Cica Active Positioning
Madecassoside can upgrade a basic Centella formula into a more active-focused Cica product. It is suitable for serums, creams, gels, toners, masks, and recovery-focused cosmetic formulas where brands need a stronger soothing and barrier-support story.
02
Suitable for Sensitive-Skin Concepts
Madecassoside is a good fit for formulas targeting reactive-looking, stressed-looking, dry, tight-feeling, or redness-prone-looking skin. It works well with panthenol, beta-glucan, ectoin, sodium hyaluronate, ceramides, cholesterol, and fatty acids.
03
Supports Barrier-Focused Formulas
Madecassoside can be used as part of a complete barrier-support system. It provides the Centella-derived active story, while moisturizing, soothing, and lipid-support ingredients help complete the formula architecture.
04
Flexible Grade Options
Noyain offers MA90, MA85, MA20, and MA10 Madecassoside grades. MA90 and MA85 are suitable for premium serums, Cica creams, and recovery-focused products, while MA20 and MA10 are more practical for toners, sheet masks, lotions, body care, and OEM/ODM private-label lines.
Evidence summary
Ingredient-level data for formulation evaluation
Noyain provides ingredient-level and preliminary screening data for Madecassoside-rich Centella active materials. Final product claims should be validated in the finished formula and reviewed according to the target market.
51%
Neutrophil aggregation inhibition at tested formula concentration in zebrafish embryo screening.
1.28
Claudin-1 relative IOD mean value in a UVB-induced HaCaT cell model.
19.15%
TEWL decrease after 28 days using 0.3% Madecassoside Gel in a 32-person evaluation.
28.59%
Red area proportion decrease after 28 days in the same human-use evaluation.
The data above are provided for cosmetic ingredient evaluation only; cosmetic manufacturers should validate finished-product claims based on their final formulas and target markets.
Application matrix
Recommended applications by product type
The selected grade should match the product type, target positioning, expected dosage, cost structure, and final claim direction.
| Product Type | Recommended Role | Suggested Grade | Formula Strategy |
|---|---|---|---|
| Sensitive skin serum | Hero or key supporting active | MA90 / MA85 | Pair with panthenol, beta-glucan, ectoin, and sodium hyaluronate. |
| Cica repair cream | Core Centella active | MA90 / MA85 / MA20 | Pair with ceramides, cholesterol, fatty acids, squalane, and panthenol. |
| Soothing toner | Supporting active | MA20 / MA10 / MA85 | Pair with humectants, allantoin, betaine, and mild preservatives. |
| Sheet mask essence | Supporting or hero active | MA20 / MA10 / MA85 | Pair with glycerin, trehalose, beta-glucan, and sodium hyaluronate. |
| Recovery-focused gel | Key active | MA90 / MA85 | Pair with PDRN, panthenol, copper tripeptide-1, and sodium hyaluronate. |
| Retinol companion cream | Comfort and barrier-support active | MA85 / MA20 | Pair with panthenol, ceramides, ectoin, and beta-glucan. |
Formula concepts
Product concept directions for OEM/ODM development
Madecassoside can be used to build different Cica, sensitive-skin, and barrier-support product lines for OEM/ODM development. The right grade should be selected based on product positioning, dosage target, cost structure, and final claim direction.
Serum
Premium Cica Serum
For high-end sensitive-skin serums, MA90 or MA85 can be used as the key active to support a clearer Madecassoside-powered Cica story.
Cream
Barrier-Support Cream
For daily repair creams and moisturizers, Madecassoside can be combined with barrier-focused ingredients to support comfort, hydration, and recovery-focused skincare positioning.
Soothing Toner
Cost-Balanced Soothing Toner
For large-volume toner, mask, or lotion projects, MA20 or MA10 can provide a more practical Centella-derived active option while maintaining a clear soothing product concept.
Cosmetic Gel
Recovery-Focused Cosmetic Gel
For post-procedure cosmetic care, after-sun care, or active-routine support, MA90 or MA85 can help build a premium recovery-focused formula story.
Formulation notes
How to use Madecassoside in cosmetic formulation
Madecassoside can be used in serums, essences, toners, creams, lotions, gels, masks, and recovery-focused cosmetic products. Final performance depends on grade, dosage, solvent system, pH, processing temperature, preservative system, and packaging.
Get Formulation GuideConfirm grade and target dosage
Define MA90, MA85, MA20, or MA10 according to product positioning and active equivalent target.
Prepare pre-dispersion
Use a suitable water or water/humectant pre-mix to improve dispersion and reduce clumping risk.
Add gradually under mixing
Avoid direct addition into a highly viscous gel or cream base.
Check pH and appearance
Evaluate clarity, sedimentation, pH drift, color, odor, and viscosity after incorporation.
Run stability before scale-up
Confirm short-term, accelerated, low-temperature, freeze-thaw, and packaging compatibility as needed.
Recipe reminder
For clear toner, essence, or gel systems, check clarity, dispersion, and precipitation risk during bench testing. Direct addition into highly viscous systems should be avoided.
Technical Specifications
Product Technical Parameters
Parameter | Specification |
|---|---|
Trade Name | MA90 / MA85 / MA20 / MA10 |
INCI Name | Madecassoside |
CAS No. | 34540-22-2 |
Source | Centella asiatica-derived active |
Ingredient Type | Triterpenoid saponin |
Appearance | White to off-white powder / white to light white powder |
Recommended Dosage | Formula-dependent; commonly evaluated around 0.05–0.2% for high-purity grades, with grade and formula validation required |
Solubility | Water-compatible; soluble in water or alcohol. Final solubility depends on grade, dosage, solvent system, pH, and formula type |
Function | Soothing, barrier support, redness appearance care, antioxidant support, sensitive-skin comfort, recovery-focused cosmetic care |
Application | Serums, creams, emulsions, lotions, gels, masks, after-sun care, post-procedure cosmetic care, Cica repair concept formulas |
Storage Condition | Store sealed in a cool, dry place. Keep container closed when not in use. Protect from moisture and unnecessary heat exposure |
Shelf Life | 24 months under recommended storage conditions |
Document support
Documentation and supply support
- COA for batch quality confirmation
- Product specification for QA and procurement review
- SDS / MSDS for safety and handling
- Technical data sheet for R&D and marketing teams
- Grade comparison sheet for MA90, MA85, MA20, and MA10
- Application and compatibility guidance
- Claim language guidance for cosmetic-friendly wording
Sample request information
To help Noyain recommend the right Madecassoside grade, please provide the following information when requesting a sample or quotation.
- Product type and target market
- Desired product positioning
- Preferred grade, if known
- Formula type and expected dosage
- Target pH and appearance requirement
- Key supporting ingredients
- Required documents
- Sample quantity and estimated bulk demand
Supplier value
Why choose Noyain as your Madecassoside supplier
Multiple grade options
MA90, MA85, MA20, and MA10 grade directions allow customers to match positioning, claim strength, formula type, and commercial budget.
Formulation-oriented support
Noyain helps customers evaluate dosage logic, application direction, compatibility, processing, and stability risks.
Clear B2B communication
Product information is structured for R&D, procurement, QA, regulatory, marketing, and OEM sales teams.
related products
Other related products
Related Documents
Technical Support Materials
COA Document
Request COATDS (Technical Data Sheet)
Request TDSSDS / MSDS
Request SDS / MSDSFormulation Guide
Get For FreeRelated Topics
Product-related articles
Ready to Develop Gentle Skincare with Madecassoside?
Request Madecassoside samples, quotation, COA, TDS, MSDS, and formulation guidance for soothing serums, moisturizing creams, masks, cleansers, and strong-active comfort formulas.
Frequently Asked Questions
Questions from Formulators and Buyers
- What is Madecassoside?
Madecassoside is a Centella asiatica-derived triterpenoid saponin active used in cosmetic formulations for soothing, sensitive skin care, barrier-support skincare, redness appearance care, and recovery-focused cosmetic concepts.
- Is Madecassoside the same as Centella extract?
No. Centella extract is a broad botanical extract containing multiple compounds. Madecassoside is a more defined Centella-derived active compound and is often used for premium Cica skincare and active-focused product positioning.
- Which Madecassoside grade should I choose?
MA90 and MA85 are suitable for premium serums, Cica repair creams, and hero-active positioning. MA20 and MA10 are more suitable for cost-balanced toners, lotions, masks, gels, and OEM/ODM formulas where Madecassoside is a supporting active.
- Is high-purity Madecassoside always better?
Not always. High-purity Madecassoside is better for premium and hero-active products, but lower grades may be more practical for large-volume formulas, masks, toners, and cost-sensitive OEM projects.
- Can Madecassoside be used with PDRN?
Yes. Madecassoside and PDRN / Sodium DNA can be combined in premium recovery-focused cosmetic formulas. This pairing is suitable for post-procedure cosmetic care, anti-aging recovery products, and high-end repair serums.
- Can Madecassoside be used with niacinamide?
Yes. Madecassoside can be combined with niacinamide in formulas for barrier support, tone care, acne-prone skin comfort, and redness appearance support. pH, dosage, and user tolerance should be evaluated.
- Is Madecassoside water-soluble?
Madecassoside can be used in water-rich cosmetic systems, but solubility and clarity depend on grade, concentration, solvent system, pH, and formula type. Pre-dispersion or pre-solubilization testing is recommended.